The Relationship of Carotid Intima-Media Thickness with Cell Adhesion Molecules and Pentraxin-3 in Patients with Psoriatic Arthritis

Abstract Aim Cardiovascular morbidity is increased in patients with psoriatic arthritis (PsA) compared to the general population. Several recent studies have indicated that pentraxin 3 (PTX-3) and cell adhesion molecules (CAMs) might be independent biomarkers of subclinical atherosclerosis. In this study, we aimed determine relationship CAMs PTX-3 carotid intima media thickness (CIMT) PsA compare CIMT serum levels these healthy controls (HCs). Method fulfilling CASPAR (Classification criteria for Psoriatic Arthritis) without traditional cardiovascular (CV) comorbidity HCs autoimmune and/or CV disease were included cross-sectional study. Carotid artery Doppler ultrasound examinations conducted by a single radiologist blinded participants’ clinical characteristics. Serum vascular molecule 1 (VCAM-1), intercellular (ICAM-1), E-selectin, concentrations analized. Results 43 (27 females, mean age 42.49±11.70 years, duration 9.37±7.96 years) 37 (28 42.16±11.38 included. regression analyses, found best predictors PsA. was significantly higher (0.63±0.18 vs. 0.49±0.10 mm, p<0.01). te group, PTX-3, ICAM-1, VCAM-1 also than HCs. correlated positively age, duration, (p<0.05). Conclusion our level comorbidity. This outcome highlights importance monitoring as risk factors patients.